Antibody discovery is rarely a one-size-fits-all process. Programs targeting therapeutics, diagnostics, or fundamental structural biology questions each demand different functional readouts, and platforms that can't adapt often limit what's discoverable.

The Beacon® Optofluidic platform enables single B cell antibody discovery with the flexibility to meet these demands. Beyond standard screening, the Beacon system supports advanced assay formats, including screening against membrane-expressed antigens, assessing pH-dependent binding, and competition assays to detect cross-reactivity against unlabeled small molecules. These capabilities enable researchers to tailor antibody discovery campaigns to identify candidates best suited for their specific application.

The webinar will begin with a brief technology overview highlighting these expanded assay capabilities and how the Beacon system supports diverse antibody discovery applications. It will then transition to Kathryn Hastie, an instructor at La Jolla Institute for Immunology, who will describe how her lab uses the Beacon system to discover antibodies against viral capsid proteins, resolve their crystal structures across multiple conformational states, map antibody-binding epitopes, and guide future therapeutic and vaccine development.


KEY TAKEAWAYS

  • Beyond Standard Screening: Discover new assays of the Bruker Beacon system for antigen-specificity assessment, including pH-dependent binding assays and competition assays to detect cross-reactivity against unlabeled small molecules.
  • From Discovery to Structure: Learn how Kathryn Hastie's lab at La Jolla Institute for Immunology uses the Beacon system to identify antibodies against viral capsid proteins and resolve their crystal structures across pre- and post-fusion states.
  • A Platform Built for Flexibility: See how Beacon's flexibility supports antibody discovery workflows spanning therapeutics, diagnostics, and structural biology research, all from a single optofluidic system.
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Speakers

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Vincent Pai
Director, Product Management, Bruker Cellular Analysis
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Kathryn M. Hastie, Ph.D.
Instructor and Director of Antibody Discovery, La Jolla Institute for Immunology
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Kathryn M. Hastie, Ph.D.
Instructor and Director of Antibody Discovery
La Jolla Institute for Immunology
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